Studies on Antibiotics. II. : Acidomycin. (2). : Antitubercular Activity of Compounds Related to Acidomycin.

Studies on the Antitubercular Compounds (XII) Effect on Antitubercular Activity of Acid Hydrazide by the Condensation with Aldehyde Shichiro

Intracutaneous injection of acidomycin (Satani's method) in the treatment of leprosy; preliminary report.

Acidomycin, an antibiotic active against Mycobacterium tuberculosis in vitro, was obtained from a culture of Streptomyces a.cidomllceticUB and its variant first isolated and named by Koichi Ogata of the Takeda Ferment Institute. The microbiological study of this streptomyces was first reported at a meeting in Hiroshima in 1951, and then at another held in Tokyo in 1952 (8. 9. 10). Since the sum...

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...

Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 μg mL(-1)), triterpenoids as bassic acid (MIC = 2.5 μg mL(-1)), α-amyrin acetate (MIC = 62.5 μg mL(-1)), a mixture of lupeol, α- and β-amyrin (MIC = 31.5 μg mL(-1)) and a mixture of lupeol, ...

Studies on Uric Acid and Related Compounds

The systematic study of the substrate specificity of mammalian xanthine oxidase has indicated a common mechanism by which various purines may be dehydrogenated (1). The results obtained also made it clear why methylated xanthines, with the exception of 1-methylxanthine (2), cannot be oxidized by xanthine oxidase to the corresponding substituted uric acids (3, 4). Therefore, another source had t...